Dr. Tom N. Grossmann

Professor of Organic Chemistry

VU University Amsterdam
Dept. of Chemistry & Pharmaceutical Sci.
De Boelelaan 1108
1081 HZ Amsterdam
The Netherlands

Chemical Genomics Centre (CGC)
of the Max Planck Society
Otto-Hahn-Str. 15
44227 Dortmund
Germany

Email: t.n.grossmann@vu.nl

ResearcherID: A-4175-2015

Curriculum Vitae

Peptide-inspired ligands for the modulation of biological function

Organic synthesis Peptidomimetics
Protein targeting and modification Subcellular localization of proteins

Ligands that selectively bind to biomolecular targets are a prerequisite for most strategies aiming at the elucidation or modulation of biological processes. The discovery of these ligands can be very challenging. Giving the huge amount of available structural data, peptide binding epitopes provide a rich source of inspiration for novel ligands. Preorganization of such peptides into their bioactive conformation or the use of rigid peptidomimetic scaffolds have been applied to ensure binding affinity and bioactivity. Notably, there is a lack of approaches for the stabilization of irregular and complex peptide structures – these are limitations that we address with our research. We use such peptide-inspired ligands for applications in proximity-induced chemical reactions and as inhibitors of protein-protein interactions.

 

Techniques and instrumentation

Chemical synthesis Solid-phase peptide synthesis
Chemical synthesis Solid-phase peptide synthesis
Protein expression & purification Peptide & protein characterization
Protein expression & purification Peptide & protein characterization
Fluorescence microscopy Protein crystallization & structure determination
Fluorescence microscopy Protein crystallization & structure determination

 

Support

European Research Council AstraZeneca Merck
Emmy Noether-Programm Bayer CropScience Boehringer Ingelheim
Bayer HealthCare