Dr. Tom N. Grossmann

Professor of Organic Chemistry

VU University Amsterdam
Dept. of Chemistry & Pharmaceutical Sci.
De Boelelaan 1108
1081 HZ Amsterdam
The Netherlands

Chemical Genomics Centre (CGC)
of the Max Planck Society
Otto-Hahn-Str. 15
44227 Dortmund

Email: t.n.grossmann@vu.nl

ResearcherID: A-4175-2015

Curriculum Vitae


Article in Osteoarthritis and Cartilage is online

By grossmannlab on Mar 21, 2018

Congratulations to Jessi Bertrand and her team! We’re glad to see StAx peptides in action.

“Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage”

A Held, A Glas, L Dietrich, M Bollmann, K Brandstädter, TN Grossmann, CH Lohmann, T Pap, J Bertrand*, DOI: 10.1016/j.joca.2018.02.908


Felix Paulußen joins our team

By grossmannlab on Jan 15, 2018

Welcome Felix – Congratulations for receiving the STAR PLUS fellowship!

All the best for your joint project with Joen Luirink (Molecular Microbiology) and Daan Geerke (Molecular Toxicology)!


Merry Christmas!

By grossmannlab on Dec 18, 2017

All the best for the holidays and the New Year!


Perspective in Cell Chemical Biology is online

By grossmannlab on Nov 17, 2017

“The therapeutic potential of PTEN modulation: Targeting strategies from gene to protein”

NM McLoughlin, C Mueller, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.10.009


Article in Chemistry – A European Journal is online

By grossmannlab on Oct 20, 2017

“Oligonucleotides with cationic backbone and their hybridization with DNA: Interplay of base pairing and electrostatic attraction”

B Schmidtgall, A Kuepper, M Meng, TN Grossmann*, C Ducho*, DOI: 10.1002/chem.201704338

Graphical Abstract

Article in the Journal of Medicinal Chemistry is online

By grossmannlab on Oct 14, 2017

“Structure-based design of macrocyclic peptides that inhibit protein-protein interactions”

DM Krüger, A Glas, ,* ,* TN Grossmann*, DOI: 10.1021/acs.jmedchem.7b01221


Communication in Chemistry – A European Journal is online

By grossmannlab on Aug 5, 2017

This communication is featured on the inside cover.

“Increased conformational flexibility of a macrocycle‒receptor complex contributes to reduced dissociation rates”

A Glas, EC Wamhoff, DM Krüger, C Rademacher*, TN Grossmann*, DOI: 10.1002/chem.201702776


Article in Cell Chemical Biology is online

By grossmannlab on Jul 27, 2017

“Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets b-Catenin Protein-Protein Interactions”

L Dietrich, B Rathmer, K Ewan, T Bange, S Heinrichs, TC Dale, D Schade, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.06.013

We thank our collaborators for their contributions!!


Congratulations to Laura Dietrich

By grossmannlab on Jul 25, 2017

Laura successfully defended her PhD thesis “Zellgängige Peptide zur Inhibition des Wnt/β-Catenin Signalwegs”.

EU research

Our work was highlighted in the latest issue of EU Research

By grossmannlab on Jul 22, 2017

Combining the best of small molecules and biologics (page 12)


Review in Angewandte Chemie is online

By grossmannlab on Feb 10, 2017

Congratulations to the entire AztraZeneca/MPI satellite team!

“New modalities for challanging targets in drug discovery”

E Valeur,* SM Gueret, H Adihou, R Gopalakrishnan, M Lemurell, H Waldmann, TN Grossmann, AT Plowright, DOI: 10.1002/anie.201611914