Prof. Dr. Tom N. Grossmann

Chair of Biomimetic Chemistry
Email: t.n.grossmann@vu.nl
ResearcherID: A-4175-2015

Curriculum Vitae

Department of Chemistry and
Pharmaceutical Sciences

Amsterdam Institute for
Molecules, Medicines and Systems

VU University Amsterdam
De Boelelaan 1108
1081 HZ Amsterdam, The Netherlands

Disclaimer/Impressum

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For more news see Twitter @TomNGrossmann

By grossmannlab on Nov 4, 2019

https://twitter.com/TomNGrossmann

UNC119a

Communication in ChemBioChem is online

By grossmannlab on Nov 4, 2019

“Lipidated stapled peptides targeting the acyl binding protein UNC119”

PM Cromm, H. Adihou, S. Kapoor, M Vazquez-Chantada, P Davey, D Longmire, E Hennes, W Hofer, P Küchler, E Chiarparin, H Waldmann*, TN Grossmann* DOI: 10.1002/cbic.201900615

Thanks for the great contributions from collaborators at the Max Planck Institute in Dortmund and at AstraZeneca!

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Article in Angewandte Chemie is online

By grossmannlab on Sep 23, 2019

“A peptide with fine-tuned flexibility inhibits NF-Y transcription factor assembly”

S Jeganathan, M Wendt, S Kiehstaller, D. Brancaccio, A Kuepper, N Pospiech, A Carotenuto, E Novellino, S Hennig*, TN Grossmann* DOI: 10.1002/anie.20190790

Thanks to Diego Brancaccio and Alfonso Carotenuto at University of Naples for contributing NMR structures of bound peptides!

P2M

Physics2Market grant

By grossmannlab on Aug 28, 2019

We’ll receive the Physics2Market grant supporting our efforts to use the INCYPRO technology to increase stability of therapeutic target proteins for screening purposes. Thanks to IXA for the support!

Read more about INCYPRO here: Pelay-Gimeno et al., Angew. Chem., 2018 and Neubacher et al., BIOspektrum, 2019

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Welcome to Alessia Amore and Alan Gerber

By grossmannlab on Aug 5, 2019

We’re happy Alessia and Alan join the team as senior scientists contributing with their expertise on protein chemistry and molecular biology, respectively!

caro

Congratulations to Carolin Müller!

By grossmannlab on Jun 25, 2019

Caro successfully defended her PhD. It’s great to see our first group member graduating from Amsterdam.

Read more about Caro’s research here: Angew. Chem. Int. Ed., 57, 17079 –17083 (2018) – open access (PDF)

Team

Article in BIOspektrum is online

By grossmannlab on May 12, 2019

BIOspektrum is featuring our protein stabilization technology and the INCYPRO team.

The article can be found here (German, open access: PDF). Read more about INCYPRO here: M Pelay-Gimeno et al., Angew. Chem., 2018

Nina3

Nina-Louisa Efrém supported by the German Academic Scholarship Foundation

By grossmannlab on Mar 28, 2019

Nina was awarded a scholarship by the Studienstifung des deutschen Volkes. Congratulations!!

In her master project, Nina develops strategies to target protein-protein interactions in the Wnt signalling pathway. Read more about our Wnt-targteing efforts here: Dietrich et al., Cell Chem. Biol., 2017

incypro

Incircular website is online!

By grossmannlab on Mar 8, 2019

Our INCYPRO technology is now implemented by Incircular Biotechnologies to stabilize proteins and enzymes for biotechnological and biomedical applications.We are suppored by Innovation Exchange Amsterdam, the European Research Council (ERC Proof-of-Concept grant) and VU Universtity Amsterdam.

If you want to learn more about INCYPRO and its implemenation follow Saskia on twitter @SaskiaNeubacher and read here: Pelay-Gimeno et al., Angew. Chem., 2018 (open access: PDF).

master students

Welcome to our new master students

By grossmannlab on Mar 6, 2019

We’re happy Shymaa Sayed (from ENS Paris-Saclay) as well as Nina-Louisa Efrém, Inez Koornneef, Brecht Ellenbroek and Steven Frölke (all from VU Amsterdam) join our group!

Jordy

Jordy Saya joins our team

By grossmannlab on Mar 1, 2019

Jordy joins our group as a postdoc supporting the stabilization of peptide and protein structures.

ERC

ERC proof of concept grant

By grossmannlab on Dec 21, 2018

Our ERC Proof-of-Concept proposal has been selected for funding. This will support our efforts to pursue the valorization of INCYPRO.

Read more here: Pelay-Gimeno et al., Angew. Chem., 2018 and Vrije Universiteit Amsterdam

cover

Article featured as Angewandte inside cover

By grossmannlab on Dec 19, 2018

Our article  “Coiled‐coil peptide beacon: A tuneable conformational switch for protein detection” (C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515) was featured as inside cover by Angewandte Chemie.

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Merry Christmas to everyone!

By grossmannlab on Dec 14, 2018
Arne defense

Congratulations to Arne Küpper!

By grossmannlab on Dec 9, 2018

Arne successfully defended his PhD. His work paves the way for our RNA-targeting efforts!

coiled-coil peptide beacon

Article in Angewandte Chemie is online

By grossmannlab on Nov 9, 2018

“Coiled‐coil peptide beacon: A tuneable conformational switch for protein detection”

C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515

Simion_Jaap

Simion Becker and Jaap Achten join the INCYPRO team

By grossmannlab on Oct 1, 2018

Simion and Jaap have a background in Science, Business & Innovation and will support our efforts regarding the commercialization of INCYPRO: In situ cyclization of proteins. Welcome!

Read more about INCYPRO here: M Pelay-Gimeno et al., Angew. Chem., 2018

NLS-StAx-h

Our β-catenin targeting Wnt inhibitor NLS-StAx-h is now commercially available

By grossmannlab on Sep 21, 2018

Bio-techne is offering NLS-StAx-h (Cat. No. 6531), a potent β-catenin antagonist that inhibits Wnt-signaling.

Read more here: Dietrich et al., Cell Chem. Biol., 2017

cYY_product

Article in Applied Microbiology and Biotechnology is online

By grossmannlab on Aug 27, 2018

Congratulations to our colleagues from Molecular Toxicology! Great to be part of the team!

“Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners”

S Ortega Ugalde, CP de Koning, K Wallraven, B Bruyneel, NPE Vermeulen, TN Grossmann, W Bitter, JNM Commandeur, JC Vos* DOI: 10.1007/s00253-018-9299-4

RNA

Article in the journal RNA is online

By grossmannlab on Aug 10, 2018

“Protein-RNA interactions: Structural characteristics and hotspot amino acids”

DM Krüger, S Neubacher, TN Grossmann*, DOI: