Prof. Dr. Tom N. Grossmann

Chair of Biomimetic Chemistry
Email: t.n.grossmann@vu.nl
ResearcherID: A-4175-2015
ORCID: 0000-0003-0179-4116

Curriculum Vitae

Department of Chemistry and
Pharmaceutical Sciences

Amsterdam Institute for
Molecules, Medicines and Systems

VU University Amsterdam
De Boelelaan 1108
1081 HZ Amsterdam, The Netherlands

Disclaimer/Impressum

image

For more news see Twitter @TomNGrossmann

By grossmannlab on Apr 28, 2020

https://twitter.com/TomNGrossmann

Tom

Author profile in Angewandte Chemie is online

By grossmannlab on Apr 28, 2020

The author profile acknowledges Tom’s 10th article in Angewandte Chemie in the last 10 years:

https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202005712

 

 

proteo

Perspective in Nature Chemistry is online

By grossmannlab on Feb 7, 2020

“Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns” (PDF)

WS Horne*, TN Grossmann*, Nature Chem., DOI: 10.1038/s41557-020-0420-9

Thanks to Seth Horne from the University of Pittsburgh for the great collaboration!

covers

Article featured as JOC supplementary Cover

By grossmannlab on Feb 7, 2020

Our article “In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability” (S Neubacher*, J Saya, A Amore, TN Grossmann, DOI: 10.1021/acs.joc.9b02490) was featured as supplementary cover in the special issue “Modern Peptide and Protein Chemistry” of the Journal of Organic Chemistry.

NickM

Welcome to VENI fellow Nick Pearce

By grossmannlab on Feb 5, 2020

Great to have Nick joining the group! He is supported by a VENI grant and will work on the multi-dataset analysis in cystal structure determination.

abstract

Article in Chemical Science is online

By grossmannlab on Jan 22, 2020

“Adapting free energy perturbation simulations for large macrocyclic ligands: How to dissect contributions from direct binding and free ligand flexibility”

K Wallraven, FL Holmelin, A Glas, S Hennig, AI Frolov*, TN Grossmann* DOI: 10.1039/C9SC04705K

Thanks to our collaborators at AstraZeneca!

group_2019

Enjoy the holidays and all the best for the New Year!!

By grossmannlab on Dec 18, 2019
Amsterdam Science

Durable enzymes for a green economy

By grossmannlab on Dec 12, 2019

Amsterdam Science magazine issue #10 is out highlighting our INCYPRO technology and their application in biocatalysis. Here you’ll find the PDF of the article.

Figure_JOC

Article in the Journal of Organic Chemistry is online

By grossmannlab on Dec 3, 2019

“In situ cyclization of proteins (INCYPRO): Cross-link derivatization modulates protein stability”
S Neubacher*, J Saya, A Amore, TN Grossmann* DOI: 10.1021/acs.joc.9b02490

ChemBioChem_cover

Communication in ChemBioChem is online

By grossmannlab on Nov 4, 2019

“Lipidated stapled peptides targeting the acyl binding protein UNC119”

PM Cromm, H. Adihou, S. Kapoor, M Vazquez-Chantada, P Davey, D Longmire, E Hennes, W Hofer, P Küchler, E Chiarparin, H Waldmann*, TN Grossmann* DOI: 10.1002/cbic.201900615

Thanks for the great contributions from collaborators at the Max Planck Institute in Dortmund and at AstraZeneca!

3

Article in Angewandte Chemie is online

By grossmannlab on Sep 23, 2019

“Constrained peptides with fine-tuned flexibility inhibit NF-Y transcription factor assembly”

S Jeganathan, M Wendt, S Kiehstaller, D. Brancaccio, A Kuepper, N Pospiech, A Carotenuto, E Novellino, S Hennig*, TN Grossmann* DOI: 10.1002/anie.20190790

Thanks to Diego Brancaccio and Alfonso Carotenuto at University of Naples for contributing NMR structures of bound peptides!

P2M

Physics2Market grant

By grossmannlab on Aug 28, 2019

We’ll receive the Physics2Market grant supporting our efforts to use the INCYPRO technology to increase stability of therapeutic target proteins for screening purposes. Thanks to IXA for the support!

Read more about INCYPRO here: Pelay-Gimeno et al., Angew. Chem., 2018 and Neubacher et al., BIOspektrum, 2019

pic3

Welcome to Alessia Amore and Alan Gerber

By grossmannlab on Aug 5, 2019

We’re happy Alessia and Alan join the team as senior scientists contributing with their expertise on protein chemistry and molecular biology, respectively!

caro

Congratulations to Carolin Müller!

By grossmannlab on Jun 25, 2019

Caro successfully defended her PhD. It’s great to see our first group member graduating from Amsterdam.

Read more about Caro’s research here: Angew. Chem. Int. Ed., 57, 17079 –17083 (2018) – open access (PDF)

Team

Article in BIOspektrum is online

By grossmannlab on May 12, 2019

BIOspektrum is featuring our protein stabilization technology and the INCYPRO team.

The article can be found here (German, open access: PDF). Read more about INCYPRO here: M Pelay-Gimeno et al., Angew. Chem., 2018

Nina3

Nina-Louisa Efrém supported by the German Academic Scholarship Foundation

By grossmannlab on Mar 28, 2019

Nina was awarded a scholarship by the Studienstifung des deutschen Volkes. Congratulations!!

In her master project, Nina develops strategies to target protein-protein interactions in the Wnt signalling pathway. Read more about our Wnt-targteing efforts here: Dietrich et al., Cell Chem. Biol., 2017

incypro

Incircular website is online!

By grossmannlab on Mar 8, 2019

Our INCYPRO technology is now implemented by Incircular Biotechnologies to stabilize proteins and enzymes for biotechnological and biomedical applications.We are suppored by Innovation Exchange Amsterdam, the European Research Council (ERC Proof-of-Concept grant) and VU Universtity Amsterdam.

If you want to learn more about INCYPRO and its implemenation follow Saskia on twitter @SaskiaNeubacher and read here: Pelay-Gimeno et al., Angew. Chem., 2018 (open access: PDF).

master students

Welcome to our new master students

By grossmannlab on Mar 6, 2019

We’re happy Shymaa Sayed (from ENS Paris-Saclay) as well as Nina-Louisa Efrém, Inez Koornneef, Brecht Ellenbroek and Steven Frölke (all from VU Amsterdam) join our group!

Jordy

Jordy Saya joins our team

By grossmannlab on Mar 1, 2019

Jordy joins our group as a postdoc supporting the stabilization of peptide and protein structures.

ERC

ERC proof of concept grant

By grossmannlab on Dec 21, 2018

Our ERC Proof-of-Concept proposal has been selected for funding. This will support our efforts to pursue the valorization of INCYPRO.

Read more here: Pelay-Gimeno et al., Angew. Chem., 2018 and Vrije Universiteit Amsterdam