Dr. Tom N. Grossmann

Professor of Organic Chemistry
Email: t.n.grossmann@vu.nl
ResearcherID: A-4175-2015

Curriculum Vitae

Department of Chemistry and
Pharmaceutical Sciences

Amsterdam Institute for
Molecules, Medicines and Systems

VU University Amsterdam
De Boelelaan 1108
1081 HZ Amsterdam, The Netherlands

RNA

Article in the journal RNA is online

By grossmannlab on Aug 10, 2018

“Protein-RNA interactions: Structural characteristics and hotspot amino acids”

DM Krüger, S Neubacher, TN Grossmann*, DOI:

PRI HotScore

Our web server “PRI HotScore” is online

By grossmannlab on Aug 7, 2018

Under https://pri-hotscore.labs.vu.nl you can upload atomic coordinates of protein-RNA complexes to identify potential amino acid hot spots in the interface.

Read more here: Krüger et al.

INCYPRO

Article in Angewandte Chemie is online

By grossmannlab on May 30, 2018

“In situ cyclization of native proteins: Structure-based design of a bicyclic enzyme”

M Pelay-Gimeno, T Bange, S Hennig, TN Grossmann*, DOI: 10.1002/anie.201804506

 

OA

Article in Osteoarthritis and Cartilage is online

By grossmannlab on Mar 21, 2018

Congratulations to Jessi Bertrand and her team! We’re glad to see StAx peptides in action.

“Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage”

A Held, A Glas, L Dietrich, M Bollmann, K Brandstädter, TN Grossmann, CH Lohmann, T Pap, J Bertrand*, DOI: 10.1016/j.joca.2018.02.908

Felix

Felix Paulußen joins our team

By grossmannlab on Jan 15, 2018

Welcome Felix – Congratulations for receiving the STAR PLUS fellowship!

All the best for your joint project with Joen Luirink (Molecular Microbiology) and Daan Geerke (Molecular Toxicology)!

gruppe1

Merry Christmas!

By grossmannlab on Dec 18, 2017

All the best for the holidays and the New Year!

GA

Perspective in Cell Chemical Biology is online

By grossmannlab on Nov 17, 2017

“The therapeutic potential of PTEN modulation: Targeting strategies from gene to protein”

NM McLoughlin, C Mueller, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.10.009

untitled

Article in Chemistry – A European Journal is online

By grossmannlab on Oct 20, 2017

“Oligonucleotides with cationic backbone and their hybridization with DNA: Interplay of base pairing and electrostatic attraction”

B Schmidtgall, A Kuepper, M Meng, TN Grossmann*, C Ducho*, DOI: 10.1002/chem.201704338

Graphical Abstract

Article in the Journal of Medicinal Chemistry is online

By grossmannlab on Oct 14, 2017

“Structure-based design of macrocyclic peptides that inhibit protein-protein interactions”

DM Krüger, A Glas, ,* ,* TN Grossmann*, DOI: 10.1021/acs.jmedchem.7b01221

Chem_cover

Communication in Chemistry – A European Journal is online

By grossmannlab on Aug 5, 2017

This communication is featured on the inside cover.

“Increased conformational flexibility of a macrocycle‒receptor complex contributes to reduced dissociation rates”

A Glas, EC Wamhoff, DM Krüger, C Rademacher*, TN Grossmann*, DOI: 10.1002/chem.201702776

2

Article in Cell Chemical Biology is online

By grossmannlab on Jul 27, 2017

“Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets b-Catenin Protein-Protein Interactions”

L Dietrich, B Rathmer, K Ewan, T Bange, S Heinrichs, TC Dale, D Schade, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.06.013

We thank our collaborators for their contributions!!

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Congratulations to Laura Dietrich

By grossmannlab on Jul 25, 2017

Laura successfully defended her PhD thesis “Zellgängige Peptide zur Inhibition des Wnt/β-Catenin Signalwegs”.

EU research

Our work was highlighted in the latest issue of EU Research

By grossmannlab on Jul 22, 2017

Combining the best of small molecules and biologics (page 12)

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Article in Nature Communications is online

By grossmannlab on Mar 23, 2017

Congratulations to the Dissmeyer and Flashman labs and thanks for having us onboard!

Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets”

MD White, M Klecker, R Hopkinson, D Weits, C Mueller, C Naumann, R O’Neill, J Wickens, J Yang, JC Brooks-Bartlett, EF Garman, TN Grossmann, N Dissmeyer*, E Flashman*, DOI: 10.1101/ncomms14690

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Poster prizes for Kerstin Wallraven and Adrian Glas

By grossmannlab on Mar 22, 2017

Congratulations to Kerstin and Adrian who recieved prizes for their proster presentations at the German Peptide Symposium!

angewandte

Review in Angewandte Chemie is online

By grossmannlab on Feb 10, 2017

Congratulations to the entire AztraZeneca/MPI satellite team!

“New modalities for challanging targets in drug discovery”

E Valeur,* SM Gueret, H Adihou, R Gopalakrishnan, M Lemurell, H Waldmann, TN Grossmann, AT Plowright, DOI: 10.1002/anie.201611914

Niall & Mathias (wide)

Niall McLoughlin and Mathias Wendt (re)join our team

By grossmannlab on Jan 2, 2017

Welcome, Niall and Mathias! All the best for your PhD research!

Translocation of an intracellular protein via peptide-directed ligation

Article in ACS Chemical Biology is online

By grossmannlab on Dec 21, 2016

“Translocation of an intracellular protein via peptide-directed ligation”

C Stiller, DM Krüger, N Brauckhoff, M Schmidt, P Janning, H Salamon, TN Grossmann*, DOI: 10.1021/acschembio.6b01013

Christmas '16 (wide)

Merry Christmas!

By grossmannlab on Dec 20, 2016

We wish you a merry Christmas and a happy New Year!

Christiane

Congratulations to Christiane Stiller

By grossmannlab on Dec 8, 2016

Christiane successfully defended her PhD thesis “Peptid-vermittelte chemische Modifikation intrazellulärer Proteine”.