Dr. Tom N. Grossmann

Professor of Organic Chemistry
Email: t.n.grossmann@vu.nl
ScopusID: 7003509298
ResearcherID: A-4175-2015

Curriculum Vitae

Department of Chemistry and
Pharmaceutical Sciences

Amsterdam Institute for
Molecules, Medicines and Systems

VU University Amsterdam
De Boelelaan 1108
1081 HZ Amsterdam, The Netherlands



For more news see Twitter @TomNGrossmann

By grossmannlab on Dec 21, 2018



ERC proof of concept grant

By grossmannlab on Dec 21, 2018

Our ERC proof of concept proposal has been selected for funding. This will support our efforts to pursue the valorization of INCYPRO.

Read more here: Pelay-Gimeno et al., Angew. Chem., 2018 and Vrije Universiteit Amsterdam


Article featured as Angewandte inside cover

By grossmannlab on Dec 19, 2018

Our article  “Coiled‐coil peptide beacon: A tuneable conformational switch for protein detection” (C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515) was featured as inside cover by Angewandte Chemie.

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Merry Christmas to everyone!

By grossmannlab on Dec 14, 2018
Arne defense

Congratulations to Arne Küpper!

By grossmannlab on Dec 9, 2018

Arne successfully defended his PhD. His work paves the way for our RNA-targeting efforts!

coiled-coil peptide beacon

Article in Angewandte Chemie is online

By grossmannlab on Nov 9, 2018

“Coiled‐coil peptide beacon: A tuneable conformational switch for protein detection”

C Mueller, TN Grossmann*, DOI: 10.1002/anie.201811515


Simion Becker and Jaap Achten join the INCYPRO team

By grossmannlab on Oct 1, 2018

Simion and Jaap have a background in Science, Business & Innovation and will support our efforts regarding the commercialization of INCYPRO: In situ cyclization of proteins. Welcome!

Read more about INCYPRO here: M Pelay-Gimeno et al., Angew. Chem., 2018


Our β-catenin targeting Wnt inhibitor NLS-StAx-h is now commercially available

By grossmannlab on Sep 21, 2018

Bio-techne is offering NLS-StAx-h (Cat. No. 6531), a potent β-catenin antagonist that inhibits Wnt-signaling.

Read more here: Dietrich et al., Cell Chem. Biol., 2017


Article in Applied Microbiology and Biotechnology is online

By grossmannlab on Aug 27, 2018

Congratulations to our colleagues from Molecular Toxicology! Great to be part of the team!

“Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners”

S Ortega Ugalde, CP de Koning, K Wallraven, B Bruyneel, NPE Vermeulen, TN Grossmann, W Bitter, JNM Commandeur, JC Vos* DOI: 10.1007/s00253-018-9299-4


Article in the journal RNA is online

By grossmannlab on Aug 10, 2018

“Protein-RNA interactions: Structural characteristics and hotspot amino acids”

DM Krüger, S Neubacher, TN Grossmann*, DOI:


Article in mBio accepted and available via bioRxiv

By grossmannlab on Aug 8, 2018

Congratulations to Jan Lowe (MCR Cambridge), Joen Luirink (VU Amsterdam) and their teams! Great collaboration!

“Structural analysis of the interaction between the bacterial cell division proteins FtsQ and FtsB”

D Kureisaite-Ciziene, A Varadajan, SH McLaughlin, M Glas, AM Sliva, R Luirink, C Mueller, T den Blaauwen, TN Grossmann, J Luirink*, J Löwe* DOI: 10.1128/mBio.01346-18; bioRxiv

PRI HotScore

Our web server “PRI HotScore” is online

By grossmannlab on Aug 7, 2018

Under https://pri-hotscore.labs.vu.nl you can upload atomic coordinates of protein-RNA complexes to identify potential amino acid hot spots in the interface.

Read more here: Krüger et al., RNA, 2018


Article in Angewandte Chemie is online

By grossmannlab on May 30, 2018

“In situ cyclization of native proteins: Structure-based design of a bicyclic enzyme”

M Pelay-Gimeno, T Bange, S Hennig, TN Grossmann*, DOI: 10.1002/anie.201804506 (open access: PDF)



Article in Osteoarthritis and Cartilage is online

By grossmannlab on Mar 21, 2018

Congratulations to Jessi Bertrand and her team! We’re glad to see StAx peptides in action.

“Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage”

A Held, A Glas, L Dietrich, M Bollmann, K Brandstädter, TN Grossmann, CH Lohmann, T Pap, J Bertrand*, DOI: 10.1016/j.joca.2018.02.908


Felix Paulußen joins our team

By grossmannlab on Jan 15, 2018

Welcome Felix – Congratulations for receiving the STAR PLUS fellowship!

All the best for your joint project with Joen Luirink (Molecular Microbiology) and Daan Geerke (Molecular Toxicology)!


Merry Christmas!

By grossmannlab on Dec 18, 2017

All the best for the holidays and the New Year!


Perspective in Cell Chemical Biology is online

By grossmannlab on Nov 17, 2017

“The therapeutic potential of PTEN modulation: Targeting strategies from gene to protein”

NM McLoughlin, C Mueller, TN Grossmann*, DOI: 10.1016/j.chembiol.2017.10.009


Article in Chemistry – A European Journal is online

By grossmannlab on Oct 20, 2017

“Oligonucleotides with cationic backbone and their hybridization with DNA: Interplay of base pairing and electrostatic attraction”

B Schmidtgall, A Kuepper, M Meng, TN Grossmann*, C Ducho*, DOI: 10.1002/chem.201704338

Graphical Abstract

Article in the Journal of Medicinal Chemistry is online

By grossmannlab on Oct 14, 2017

“Structure-based design of macrocyclic peptides that inhibit protein-protein interactions”

DM Krüger, A Glas, ,* ,* TN Grossmann*, DOI: 10.1021/acs.jmedchem.7b01221


Communication in Chemistry – A European Journal is online

By grossmannlab on Aug 5, 2017

This communication is featured on the inside cover.

“Increased conformational flexibility of a macrocycle‒receptor complex contributes to reduced dissociation rates”

A Glas, EC Wamhoff, DM Krüger, C Rademacher*, TN Grossmann*, DOI: 10.1002/chem.201702776